The next phase of development on the Greenwich Peninsula scheme is being prepared for by Lend Lease Europe and Quintain Estates & Development.
The scheme includes the creation of a new sustainable business district with offices, apartments and retail space in the SE10 area.
About 250,000 square feet of office space is due to be planned by architectural firm Fletcher Priest, which recently collaborated with fellow architect Renzo Piano, who developed the Central St Giles development in Central London.
The office area will be situated opposite to Peninsula Square.
Old plans to develop a residential area with 230 homes may also be revived.
Head of development at Lend Lease, Richard Cable, said the first phase of the development has shown some encouraging results; almost three quarters of the 312,500 square feet of office space created in two fully erected buildings has been leased.
He added: “This is the next logical site to bring forward and we want to create an outline plan for the plot for a prospective prelet next year”.
Transport for London will be tenanting one of the buildings in the first phase at 14 Pier Walk taking up 196,000 square feet of space. The other office block at 6 Mitre passage will be partially taken up by Greenwich Borough Council.
The district will be accessible through the Jubilee Underground line and will neighbour the O2 arena.